Dapoxetine is not intended for regular daily use – you should only take it before you anticipate having sex. An overview of pharmacotherapy in premature ejaculation. Importantly, clear evidence was found for improvements in interpersonal relationships, suggesting that both sexual partners benefitted from dapoxetine treatment. Important information about all medicines Never take more than the prescribed dose. Studies with concomitant use of dapoxetine and phosphodiesterase type 5 inhibitors do not show any significant interaction with tadalafil 20 mg or sildenafil mg. How to take dapoxetine tablets Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack.Dapoxetine is prescribed for the treatment of premature ejaculation. Take one tablet hours before you have sex. The most common side-effects include feeling dizzy or faint, and feeling sick (nausea). Drinking a full glass of water at the same time as taking the tablet can reduce these effects. Dapoxetine is the D-enantiomer of LY and is times more potent as a serotonin reuptake inhibitor than the L-enantiomer. Dapoxetine was in phase I clinical trials in the US with Eli Lilly as an antidepressant, but no recent development has been reported for . Development and regulatory approval of drugs specifically for the treatment of PE will reduce reliance on off-label treatments and serve to fill an unmet treatment need. The objective of this article is to review evidence supporting the efficacy and safety of dapoxetine in the treatment of PE.