Most of the pharmacotherapeutic options target neurotransmitters such as serotonin and oxytocin that have a role in the ejaculation mechanism. Pharmacol Ther ; On-Demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, Double-Blind Fixed-Dose study with stopwatch assessment. Also, they may be prescribed alone or with other treatments. Basic questions to ask your doctor The list below suggests questions to ask your health care provider about premature ejaculation. Publication types.Current standard treatment regimens include behavioural therapies, topical anaesthetics, dapoxetine and other selective serotonin reuptake inhibitors (SSRIs). Most of the pharmacotherapeutic. Dresser M., Desai D., Gidwani S., Seftel A., Modi N. (a) Dapoxetine, a novel treatment for. We systematically searched Embase, PubMed, Cochrane, of Knowledge, test1.ru and Clinical test1.ru for studies reporting dapoxetine in men with premature ejaculation. Efficacy endpoints included intravaginal ejaculatory latency times (IELT), personal distress related to ejaculation (PDRE) and treatment-emergent adverse events (TEAEs) was.