Pearlman says the availability of an easy-to-access treatment for men dealing with ED is welcome news. When oral medications might not be safe Check with your health care team before you take any medicine for erectile dysfunction. You can take it in a small dose daily or in a larger dose as needed. This is the same principle on which Sildenafil itself works. Stress Management Stress and anxiety can affect your sexual performance, whilst stress about your sexual performance can affect it even further.Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. This boosts blood flow and helps you get an erection from sexual activity. Is There Anything Over the Counter That Works Like Viagra? There are several medications and treatments used to treat erectile dysfunction (ED, impotency), including Viagra (sildenafil), testosterone replacement therapy, penile self-injection, and others. Is There Anything Over the Counter That Works Like Viagra? There are several medications and treatments used to treat erectile dysfunction (ED, impotency), including .