Figure 6 shows that regardless of the baseline levels of function, subsequent function in patients treated with VIAGRA was better than that seen in patients treated with placebo. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction 80 mg t. The result of smooth muscle cell target protein phosphorylation is a decrease in intracellular calcium, increased efflux of potassium, and deactivation of myosin light chain kinase, ultimately causing smooth muscle relaxation. The onset of action can occur within 30 minutes, while the duration of the effect can last up to 18 hours. Your health information should remain between your provider and yourself.Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension. It is in the phosphodiesterase-5 inhibitor (PDE5-I) class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. Knowledge . 67% average discount. Based on the average user savings between January and September Search for your prescription on our site or mobile app to see how . Medications Prescribed: Viagra, Cialis, Cialis Daily, Levitra, tadalafil, sildenafil, vardenafil. Generic offered: Yes. Why We Chose It. The simple combination of Rex MD’s online platform, its helpful customer service, and the abundance of ED treatment options make it a one-stop shop for all your sexual health needs.